Formation and Control of Carboxyl- and Hydroxyl-Related Impurities in Peptide Synthesis — Using Asp/Glu and Ser/Thr Residue Side Reactions as Examples
In peptide synthesis, impurities do not always originate from “incomplete coupling” or “incomplete deprotection.” Many quality issues arise because certain functional groups enter undesired reaction pathways under specific conditions. Carboxyl and hydroxyl groups are two typical examples. ...
危险品化学品经营许可证(带存储)