Conformational Control by Proline Derivatives and Their Medicinal Chemistry Effects: Ring Puckering, Amide Cis–Trans Isomerization, and Drug Properties
Proline and its derivatives are widely found in small-molecule drugs, peptidomimetics, and therapeutic peptides. Recent medicinal chemistry studies have shown that structures such as 4-fluoroproline, 4-(trifluoromethyl)proline, α-substituted proline, and bicyclic proline can alter molecular ...
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