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Microglia-containing human brain organoids (MC-HBOs) integrate neural cells, glial cells, and resident immune cells of the central nervous system within a three-dimensional culture system and can be used to analyze the roles of microglia in brain development, neuroinflammation, and ...
Tumor organoids can retain some of the histological features, driver alterations, and clonal differences of a patient’s tumor, providing expandable human-derived models for studying tumor evolution, therapeutic sensitivity, and mechanisms of drug resistance.
Organoids can self-organize from tissue stem cells, primary cells, or pluripotent stem cells in a three-dimensional environment and partially reconstruct the cellular composition, spatial architecture, and functional characteristics of organs. They provide models that more closely resemble in ...
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