Sulfonyl Hydrazide-Mediated Introduction of Small C(sp³) Fragments: Nickel-Catalyzed Cross-Coupling, Medicinal Chemistry Applications, and Reagent Selection
During lead optimization, medicinal chemists often need to introduce small C(sp³) fragments—such as methyl, cyclopropyl, difluoromethyl, hydroxymethyl, oxetanyl, and bicyclo[1.1.1]pentyl groups—onto the same molecular scaffold to investigate how changes in substituents affect biological ...
危险品化学品经营许可证（带存储）