The CEACAM family participates in epithelial homeostasis through cell adhesion, receptor signaling, and immune regulation. CEACAM5 and CEACAM6 are aberrantly overexpressed in multiple solid tumors and provide important targets for tumor biomarkers, antibody-drug conjugates, and cellular ...
CAR-T cell therapy has achieved substantial efficacy in multiple hematological malignancies, but ex vivo cell manufacturing requires a long production cycle and involves complex procedures. The development of targeted in vivo delivery technologies has provided a new engineering pathway for ...
CD2-CD58 interactions stabilize contact between immune cells and target cells and participate in the organization of T-cell and NK-cell immune synapses, amplification of activation signals, and maintenance of effector functions. Loss of CD58 or insufficient CD2 signaling can weaken antitumor ...