Regulation of Acid-Base Homeostasis by the Carbonic Anhydrase Family and Its Roles in Targeted Therapy for Cancer and Related Diseases
Carbonic anhydrases maintain tissue acid-base balance and gas transport by catalyzing the reversible conversion of carbon dioxide and bicarbonate. Abnormal expression of different isoenzymes can contribute to tumor acidification, glaucoma, abnormal neuronal excitability, and metabolic disorders.
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