Mechanisms of Action, Design Strategies, and Research Evaluation of Targeted Covalent Inhibitors
Targeted covalent inhibitors (TCIs) first form a noncovalent complex with the target protein and then form a covalent bond with a specific amino acid residue near the binding pocket. Their development focuses on increasing target occupancy and duration of action while controlling warhead ...
危险品化学品经营许可证(带存储)