Role of Aberrant Receptor Tyrosine Kinase Signaling in Tumorigenesis, Precision Classification, and Targeted Therapy
Receptor tyrosine kinases (RTKs) regulate cell proliferation, survival, migration, and differentiation through tyrosine phosphorylation. RTK mutations, amplifications, fusions, or abnormal expression can continuously activate MAPK, PI3K/AKT, STAT, PLC, and other signaling pathways, thereby ...
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