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SPANC

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Strain-promoted alkyne-nitrone cycloaddition (SPANC)

SPAAC can be carried out efficiently. On the one hand, the chemical potential energy of azide and alkyne substrates as reactants is very high. Diaryl-strained-cyclooctynes, such as dibenzylcyclooctyne (DIBO), have found application in reacting with 1,3-nitrones in strain-promoted alkyne-nitrone ...

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