3,3-disubstituted oxetane

Design Logic of Fluorinated 3,3-Disubstituted Oxetane Building Blocks: Structural Construction and Modulation of Amine Basicity, Lipophilicity, and Metabolic Stability

Lead compound optimization usually requires the simultaneous modulation of target activity, solubility, membrane permeability, metabolic stability, and nonspecific binding. A structural change may improve one property while shifting another outside the desired range. For example, basic amines ...