Sirtuins真的是“长寿蛋白”吗？NAD⁺依赖性调控与衰老机制
Sirtuins是由SIRT1—7组成的NAD⁺依赖性去酰化酶家族，参与代谢、DNA修复、线粒体稳态和炎症调控。动物研究提示部分成员可改善健康寿命，但目前尚无直接证据证明其能够延长人类最大寿命。
主题
NAD⁺
以下是知识库中与该主题相关的实验方案、常见问题、指南与技术文章。
4 项资源 · 实验方案、常见问题与文章
Are Sirtuins Really “Longevity Proteins”? NAD⁺-Dependent Regulation and Mechanisms of Aging
Sirtuins are a family of NAD⁺-dependent deacylases comprising SIRT1–7 and are involved in metabolism, DNA repair, mitochondrial homeostasis, and inflammatory regulation. Animal studies suggest that certain members may improve healthspan, but there is currently no direct evidence that they can ...
Regulatory Mechanisms of Aging-Related Nutrient Sensing, Inflammation, and Homeostatic Signaling Pathways
Aging involves persistent dysregulation of nutrient sensing, energy metabolism, protein homeostasis, and chronic inflammation. IIS, mTOR, AMPK, NF-κB, and Sirtuins are interconnected through nodes including AKT, FOXO, ULK1, and NAD⁺ and jointly regulate cell growth, autophagy, stress adaptation, ...
衰老相关营养感知、炎症与稳态信号通路的调控机制
衰老涉及营养感知、能量代谢、蛋白质稳态和慢性炎症的持续失衡。IIS、mTOR、AMPK、NF-κB和Sirtuins通过AKT、FOXO、ULK1及NAD⁺等节点相互连接，共同调控细胞生长、自噬、应激适应和衰老相关分泌表型。
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