Why Proximity to Cysteine Does Not Necessarily Lead to Covalent Bond Formation: Warhead Reactivity, Reaction Geometry, and Target-Site Microenvironment
Cysteine is one of the amino acid residues most frequently exploited in targeted covalent drug discovery. Its side-chain thiol has substantial nucleophilic potential and can form stable covalent bonds with electrophilic groups such as acrylamides. Targeted covalent inhibitors typically first ...
危险品化学品经营许可证（带存储）