Polarity Exposure and Passive Membrane Permeability of bRo5 Molecules: TPSA, EPSA, ETR, and Molecular Chameleonicity
In medicinal chemistry, physicochemical properties such as molecular weight, lipophilicity, and the numbers of hydrogen-bond donors and acceptors are commonly used to assess the risk of poor solubility or low membrane permeability. Lipinski’s Rule of Five (Ro5) established empirical ...
危险品化学品经营许可证（带存储）