PolQi2: Potent DNA Polymerase Theta Inhibitor for Research
PolQi2 is a selective inhibitor of DNA Polymerase Theta (Pol θ), supporting DNA repair, cancer biology, and BRCA-deficiency research applications.
主题
synthetic lethality
用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
4 项资源 · 实验方案、常见问题与文章
Dual Vulnerabilities of MSI-H Tumors: Immune Responses and Synthetic Lethality with WRN
High microsatellite instability (microsatellite instability-high, MSI-H) is a genomic phenotype resulting from defective DNA mismatch repair. The continuous accumulation of insertion–deletion mutations generates frameshift neoantigens that increase tumor immune visibility while also producing ...
How Does MTAP Loss Reshape PRMT5 Dependency?
MTAP loss disrupts the methionine salvage pathway, resulting in the accumulation of 5′-methylthioadenosine (MTA) and partial inhibition of PRMT5 activity. Cancer cells consequently enter a state with limited PRMT5 functional reserve and develop greater dependence on residual PRMT5 activity and ...
How Does MTAP Deletion Create a Therapeutic Window for PRMT5 Inhibition? — Mechanistic Basis from MTA Accumulation to MTA-Cooperative PRMT5 Inhibitors
In 2016, two independent studies published in Science found that cancer cells deficient in methylthioadenosine phosphorylase (MTAP) were more sensitive to partial depletion of protein arginine methyltransferase 5 (PRMT5).[1,2] This finding emerged from large-scale functional genomic screens and ...
相关主题
常与免疫学实验一起研究的技术。
危险品化学品经营许可证（带存储）