PolQi2: Potent DNA Polymerase Theta Inhibitor for Research
PolQi2 is a selective inhibitor of DNA Polymerase Theta (Pol θ), supporting DNA repair, cancer biology, and BRCA-deficiency research applications.
主题
synthetic lethality
以下是知识库中与该主题相关的实验方案、常见问题、指南与技术文章。
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Dual Vulnerabilities of MSI-H Tumors: Immune Responses and Synthetic Lethality with WRN
High microsatellite instability (microsatellite instability-high, MSI-H) is a genomic phenotype resulting from defective DNA mismatch repair. The continuous accumulation of insertion–deletion mutations generates frameshift neoantigens that increase tumor immune visibility while also producing ...
How Does MTAP Loss Reshape PRMT5 Dependency?
MTAP loss disrupts the methionine salvage pathway, resulting in the accumulation of 5′-methylthioadenosine (MTA) and partial inhibition of PRMT5 activity. Cancer cells consequently enter a state with limited PRMT5 functional reserve and develop greater dependence on residual PRMT5 activity and ...
How Does MTAP Deletion Create a Therapeutic Window for PRMT5 Inhibition? — Mechanistic Basis from MTA Accumulation to MTA-Cooperative PRMT5 Inhibitors
In 2016, two independent studies published in Science found that cancer cells deficient in methylthioadenosine phosphorylase (MTAP) were more sensitive to partial depletion of protein arginine methyltransferase 5 (PRMT5).[1,2] This finding emerged from large-scale functional genomic screens and ...
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