主题

Drug discovery

用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。

16 项资源 · 实验方案、常见问题与文章
faq

1-(4-Fluorophenyl)pyrazole: Properties, Uses & FAQs

Explore key properties, synthesis context, and research applications of 1-(4-fluorophenyl)pyrazole, a fluorinated N-arylpyrazole building block for drug discovery.

更新于 2026年10月阅读12分钟
article

Why Do So Many Molecules Incorporate an “Oxadiazole Ring”? A Stability-Oriented Design Guide from Structural Effects to Application Storylines (with Product Navigation Tables 1–3)

In drug discovery, chemical biology, and organic optoelectronic materials development, rework is often not caused by the “core function” failing. More commonly, it stems from insufficient stability and controllability of the results: along the same route and within the same structural family, ...

更新于 2026年3月阅读12分钟
article

Late-Stage Fluorination Toolbox: “Minimally Invasive Upgrades” for Lead Candidates: Four “Fluorine Knobs” → Two major routes (electrophilic vs nucleophilic) → An ¹⁸F-PET tracer branch → Selection navigation & representative product list

In drug discovery, many molecules end up stuck in the same awkward spot: potency is good, but exposure is insufficient; selectivity looks fine, but metabolism is too fast; in vitro is beautiful, yet in vivo distribution is disappointing. In those moments, you usually don’t want to rebuild the ...

更新于 2026年1月阅读12分钟
article

戊烷骨架药物“变身”技术获新突破:一锅法合成二氟双环[1.1.1]戊烷

大多药物分子中普遍存在苯环结构,然而苯环可能引发一系列代谢问题。为了应对这一“副作用”,科学家们积极探索各种替代苯环的结构。近期,美国埃默里大学的研究团队宣布一项创新的方法,能够将含有苯环的药物分子改良成具有二氟双环[1.1.1]戊烷结构的化合物。该方法采用环丙烷化反应生成3-芳基双环[1.1.0]丁烷,随后与同一反应瓶中的二氟羰基发生反应,迅速合成2,2-二氟氧代环[1.1.1]戊烷。这一策略充分发挥了重氮化合物的模块化合成特性,成功制备了2,2-二氟双环[1.1.1]戊烷,是以往报道的方法所无法达成的,为合成不同环系统和功能的分子提供了崭新的途径。 ...

更新于 2024年1月阅读12分钟

相关主题

常与免疫学实验一起研究的技术。