Molecular Recognition Basis of Amide Bioisosteric Replacement: Hydrogen Bonding, Linker Geometry, and Receptor Functional Outcomes—Using the AHL–LuxR-Type Quorum-Sensing Receptor System as an Example
The amide group possesses both hydrogen-bond donor and hydrogen-bond acceptor capabilities, together with well-defined local conformational characteristics. Resonance restricts rotation about the amide C—N bond relative to an ordinary C—N single bond, and the amide linkage generally exhibits a ...
危险品化学品经营许可证（带存储）