α-defensins

Molecular Classification, Antimicrobial Mechanisms, and Mucosal Immune Regulation of the Defensin Family

Defensins are cysteine-rich cationic antimicrobial peptides produced primarily by neutrophils, intestinal Paneth cells, and various mucosal epithelial cells. They can directly disrupt microbial membranes, entrap pathogens, recruit immune cells, and regulate the mucosal microbiota, making them ...