autophagy–lysosome

From PROTAC to Non-Ubiquitin–Proteasome Degradation: Mechanisms and Selection of LYTAC, ATTEC, AUTAC, and BacPROTAC

Classical PROTACs rely on E3 ubiquitin ligases and the proteasome to eliminate intracellular target proteins, but they are difficult to apply to extracellular proteins, large-scale cellular components, and bacterial proteins. LYTAC, ATTEC, AUTAC, and BacPROTAC respectively utilize ...