Boron-containing pharmacophore

Target Recognition by Boron-Containing Pharmacophores: Tetrahedral-State Mimicry, cis-Diol Trapping, and Bimetal-Center Coordination

Pharmacophores such as boronic acids, cyclic boronic acids, and benzoxaboroles share a common coordination-chemical feature: the boron center can interconvert between a three-coordinate, approximately trigonal-planar state and a four-coordinate, approximately tetrahedral state. Three-coordinate ...