T-cell engager

T-Cell Engagers: From Bispecific Bridging to Directed Immune Cytotoxicity

T-cell engagers (TCEs) are immunotherapeutic molecules that simultaneously recognize T cells and specific target cells, thereby inducing directed T-cell cytotoxicity. In cancer research, a classical TCE binds a tumor-cell surface antigen through one arm and T-cell CD3 through the other. This ...