Are Sirtuins Really “Longevity Proteins”? NAD⁺-Dependent Regulation and Mechanisms of Aging
Sirtuins are a family of NAD⁺-dependent deacylases comprising SIRT1–7 and are involved in metabolism, DNA repair, mitochondrial homeostasis, and inflammatory regulation. Animal studies suggest that certain members may improve healthspan, but there is currently no direct evidence that they can ...
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