ENPP1为何成为STING通路的新靶点？
ENPP1是位于细胞外核苷酸代谢网络中的膜结合酶，可降解肿瘤来源的2′,3′-cGAMP，并通过AMP–CD73途径促进腺苷生成。靶向ENPP1可保护细胞外cGAMP，恢复其对宿主免疫细胞STING通路的激活。
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cGAS
用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
4 项资源 · 实验方案、常见问题与文章
Why Has ENPP1 Become a New Target in the STING Pathway?
ENPP1 is a membrane-associated enzyme in the extracellular nucleotide-metabolism network that can degrade tumor-derived 2′,3′-cGAMP and promote adenosine production through the AMP–CD73 pathway. Targeting ENPP1 protects extracellular cGAMP and restores its ability to activate the STING pathway ...
cGAS–STING通路如何参与渐冻症神经炎症？
在渐冻症中，异常积累的TDP-43可损伤线粒体，促使线粒体DNA进入细胞质。cGAS识别这些异常DNA后生成2′,3′-cGAMP并激活STING，继而启动TBK1–IRF3和NF-κB信号，将线粒体损伤转化为持续性神经炎症。cGAS–STING通路由此成为连接TDP-43病理与运动神经元损伤的重要分子轴。 ...
How Does the cGAS–STING Pathway Contribute to Neuroinflammation in Amyotrophic Lateral Sclerosis?
In amyotrophic lateral sclerosis, abnormally accumulated TDP-43 can damage mitochondria and promote the release of mitochondrial DNA into the cytoplasm. After recognizing this abnormal DNA, cGAS generates 2′,3′-cGAMP and activates STING, subsequently initiating TBK1–IRF3 and NF-κB signaling and ...
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