How Does the cGAS–STING Pathway Contribute to Neuroinflammation in Amyotrophic Lateral Sclerosis?
In amyotrophic lateral sclerosis, abnormally accumulated TDP-43 can damage mitochondria and promote the release of mitochondrial DNA into the cytoplasm. After recognizing this abnormal DNA, cGAS generates 2′,3′-cGAMP and activates STING, subsequently initiating TBK1–IRF3 and NF-κB signaling and ...
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