Why Has ENPP1 Become a New Target in the STING Pathway?
ENPP1 is a membrane-associated enzyme in the extracellular nucleotide-metabolism network that can degrade tumor-derived 2′,3′-cGAMP and promote adenosine production through the AMP–CD73 pathway. Targeting ENPP1 protects extracellular cGAMP and restores its ability to activate the STING pathway ...
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