Why Is the meta-Fluoropyridine Motif Difficult to Make? Understanding the Synthetic Logic of Stable Enamine Building Blocks from the Risks of the Balz–Schiemann Reaction
Fluoropyridines can be divided into three positional isomers: ortho, meta, and para. For synthetic chemistry, these three isomers do not present the same level of difficulty. Ortho- and para-fluoropyridines can usually be obtained through well-established halogen-exchange reactions, commonly ...
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