The MCM protein family is a core component of DNA replication licensing and replication origin activation. MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7 jointly form the MCM2-7 complex, which is loaded onto replication origins in G1 phase and forms the CMG helicase with CDC45 and GINS in S phase, ...
The cell cycle is an ordered process through which cells complete DNA replication, chromosome segregation, and cell division. The DNA damage response (DDR) is responsible for pausing the cell cycle and initiating repair when replication errors, DNA breaks, or replication stress occur.