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Oligonucleotides

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Oligonucleotide synthesis

Over the years, oligonucleotide synthesis methods have evolved: from Michelson and Todd's early H-phosphonate and phosphoric acid triglyceride methods, and Khorana's phosphodiester method in the 1950s, to the revisiting of the phosphoric acid triglyceride method in the 1960s and the phosphite ...

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