γ-Secretase Inhibitors

γ-Secretase Inhibitors

γ-Secretase is a multi-subunit enzyme complex that catalyzes the cleavage of various transmembrane proteins, including amyloid precursor protein (APP) and Notch. Processing of APP by γ-secretase leads to the production of amyloid-β peptides, which aggregate to form the amyloid plaques that are a ...