Optimization of cross-coupling reaction conditions commonly treats the “type of base” and the “equivalents of base” as clearly defined variables. For example, “sodium ethoxide (NaOEt), 3.0 equiv” means that the corresponding mass is weighed according to the molecular weight of NaOEt and is then ...
Cross-coupling refers to the connection of two molecular fragments under the action of a metal catalyst to form a new chemical bond. In organic synthesis, these reactions are most commonly used to construct carbon–carbon bonds, and they have also been widely extended to carbon–nitrogen and ...
In pharmaceuticals, agrochemical intermediates, and organic functional materials, building C–C bonds is rarely a one-off “do it once and done” task. The same transformation tends to reappear across different substrates, different functional-group combinations, different scales, and different ...
Due to the small radius of fluorine atom and its strongest electronegativity (4.0), the introduction of fluorine atom will change the polarity direction of C-F bond and the electron cloud distribution of the whole molecule, which will affect the dipole moment, acidity and basicity of the ...