CAR-T cell therapy has achieved substantial efficacy in multiple hematological malignancies, but ex vivo cell manufacturing requires a long production cycle and involves complex procedures. The development of targeted in vivo delivery technologies has provided a new engineering pathway for ...
Natural lentiviruses are a category of retroviruses (e.g., HIV-1) characterized by chronic infection and inherent pathogenicity. In contrast, lentiviral vectors are engineered, safety-modified tools derived from natural lentiviruses. By removing pathogenic genes while retaining efficient gene ...
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