3D Building Blocks

One Atom Can Change a Drug’s Fate: Atom-Level Knobs and a Functional-Group Toolbox for Medicinal Chemistry (Methyl / Halogen Bonding / 3D Building Blocks / Late-Stage Fluorination + Product-Selection Tables)

Many people imagine drug discovery as “building with LEGO blocks”: as long as the big fragments are assembled correctly, the job is done. In reality, it is closer to a precision mixing console—a single atom or a small functional group can simultaneously alter binding affinity, selectivity, ...