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small-molecule drugs

用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。

2 项资源 · 实验方案、常见问题与文章

article

Medicinal Chemistry Value of Heteroatom-Containing Small-Ring Spirocycles: Classical Heterocycle Replacement and Three-Dimensional Exit Vector Remodeling

In small-molecule drug design, saturated heterocycles such as piperidine, piperazine, morpholine, and tetrahydropyran are frequently used because they are structurally stable, their synthetic routes are well established, commercial building blocks are widely available, and they can provide basic ...

更新于 2026年7月阅读12分钟

article

From Piperidine to Pyridine: The “Most Common N-Heterocycle” Shift in FDA Small-Molecule New Drugs (2013–2023) and a Selection Guide (Tables 1–4)

If we think of small-molecule drugs as combinations of “functional modules,” N-heterocycles are among the most frequently used modules. A striking change from recent decade-level statistics is that the #1 most frequently occurring N-heterocycle has “passed the baton”—from piperidine to pyridine. ...

更新于 2026年1月阅读12分钟

Medicinal Chemistry Value of Heteroatom-Containing Small-Ring Spirocycles: Classical Heterocycle Replacement and Three-Dimensional Exit Vector Remodeling

From Piperidine to Pyridine: The “Most Common N-Heterocycle” Shift in FDA Small-Molecule New Drugs (2013–2023) and a Selection Guide (Tables 1–4)

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