pyridinone

Pyridinones as “Property Knobs” in Drug Design: From Tautomers and H-Bonding Fingerprints to Product Selection (Tables A–C)

A large part of medicinal chemistry optimization is really “local part replacement”: instead of rebuilding the scaffold from scratch, you swap an aromatic ring/heteroaromatic ring for a functional module with a more suitable hydrogen-bonding fingerprint, more controllable polarity, and more ...