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The BAFF pathway and the PD-1 pathway represent two typical directions in immune regulation by therapeutic monoclonal antibodies. The BAFF pathway mainly regulates B-cell survival, maturation, and autoantibody production, making it suitable for studies related to autoimmunity and abnormal ...
BAFF通路与PD-1通路分别代表治疗性单克隆抗体免疫调控中的两种典型方向。BAFF通路主要调节B细胞存活、成熟和自身抗体产生，适用于自身免疫和体液免疫异常相关研究；PD-1通路主要调节T细胞抑制、耗竭和抗肿瘤免疫反应，适用于肿瘤免疫和慢性抗原刺激状态下的免疫功能恢复。 ...
Programmed cell death protein 1, also known as PD-1 and CD279, is a cell surface receptor that plays an important role in downregulating the immune system and promoting self-tolerance by inhibiting T cell inflammatory activity. In humans, it is encoded by the PDCD1 gene. PD-1 is a member of the ...
程序性细胞死亡蛋白1，又称PD-1和CD279，是一种细胞表面受体，通过抑制T细胞炎症活性，在下调免疫系统和促进自我耐受方面发挥重要作用。在人类中，它由PDCD1基因编码。PD-1是免疫球蛋白超家族的一员，在t细胞和前b细胞上表达。PD-1作为受体，有两个配体PD-L1 (B7-H1)和PD-L2 ...
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