TGF-β信号转导通路的结构基础、转导分支与研究应用
TGF-β信号转导通路是调控细胞命运、组织稳态与病理重塑的重要分子网络。该通路以配体活化、受体复合体组装和Smad依赖性转录调控为核心，同时与ERK、JNK、p38等非Smad分支交叉，广泛参与纤维化、上皮-间质转化、免疫抑制和肿瘤进展等过程。 ...
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EMT
用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
4 项资源 · 实验方案、常见问题与文章
Structural Basis, Transduction Branches, and Research Applications of the TGF-β Signaling Pathway
The TGF-β signaling pathway is an important molecular network that regulates cell fate, tissue homeostasis, and pathological remodeling. This pathway is centered on ligand activation, receptor complex assembly, and Smad-dependent transcriptional regulation, while also intersecting with non-Smad ...
Transforming Growth Factor-β: Family Lineages, Receptor Signaling Networks, and Key Technical Points for Applications
Transforming growth factor-β (TGF-β) is a core member of a multifunctional cytokine family and exerts systemic influence in embryonic development, immune homeostasis, tissue repair, extracellular matrix (ECM) remodeling, and regulation of the tumor microenvironment. TGF-β initiates signaling ...
转化生长因子-β：家族谱系、受体信号网络与应用技术要点
转化生长因子-β（Transforming Growth Factor-β，TGF-β）是多功能细胞因子家族的核心成员，在胚胎发育、免疫稳态、组织修复、细胞外基质重塑与肿瘤微环境调控中具有系统性影响。TGF-β通过I型与II型丝氨酸/苏氨酸激酶受体复合体启动信号转导，经典通路以SMAD2/3- ...
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