Carbonic anhydrases maintain tissue acid-base balance and gas transport by catalyzing the reversible conversion of carbon dioxide and bicarbonate. Abnormal expression of different isoenzymes can contribute to tumor acidification, glaucoma, abnormal neuronal excitability, and metabolic disorders.
Angiogenesis is a biological process in which new blood vessels arise from the pre-existing vasculature to maintain tissue perfusion and meet cellular demands for oxygen and nutrients. Its initiation and progression are finely orchestrated by multi-layer regulators, including soluble growth ...