The cytoskeleton is a dynamic fibrous network composed of microfilaments, microtubules, and intermediate filaments, mainly consisting of actin, tubulin, and different types of intermediate filament proteins. The cytoskeleton not only maintains cell morphology, cell polarity, and intracellular ...
Colchicine is a prototypical small-molecule perturbant of the microtubule system. By binding tubulin and inhibiting microtubule polymerization, it disrupts spindle assembly and stability, thereby blocking cell division, inducing abnormal chromosome behavior, and driving changes in ploidy. ...
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