Neutrophils contain numerous effector proteins involved in host defense, including MPO, NE, Cathepsin G, PR3, BPI, Azurocidin, Lactoferrin, and Lysozyme. In human neutrophils, HNPs are also prominent α-defensin effectors. These proteins cooperate in pathogen clearance, whereas their persistent ...
Proteases are extensively involved in inflammatory amplification, barrier disruption, matrix remodeling, and structural destabilization in respiratory and vascular diseases.
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