Amide bond formation is not as simple as merely “choosing a reagent that can activate a carboxylic acid.” Many coupling systems can connect an acid and an amine, but they do not channel the carboxylic acid through the same activation pathway, they generate different activated intermediates, they ...
Amide bond formation is one of the most common fundamental reactions in organic synthesis, medicinal chemistry, and peptide chemistry. For a long time, when evaluating coupling reagents, the first concerns were usually whether the reaction was fast enough, whether the yield was high enough, and ...
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