Racemic

Low Racemization in Peptide Synthesis Is Not Just About Reagent Choice: Stereochemical Risk During the Activation Stage and Practical Strategies for Experimental Control

“Racemization” in peptide synthesis is often discussed as if it were mainly a question of whether one coupling reagent is better than another. From the standpoint of reaction chemistry, however, what deserves greater caution is the period after the carboxylic acid has been activated. In many ...