用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
Inflammasomes are important cytoplasmic signaling complexes of the innate immune system that sense infection, cellular injury, and metabolic abnormalities. They activate inflammatory Caspases, promote the maturation of IL-1β and IL-18, and drive Gasdermin-mediated pyroptosis. Inflammasomes such ...
Pyroptosis is a proinflammatory form of regulated cell death mediated by pore formation by Gasdermin family proteins. This process is generally initiated by inflammasome assembly and inflammatory caspase activation, leading to increased plasma membrane permeability, cellular swelling and ...
Neuroinflammation is an inflammatory response formed in the nervous system under conditions such as infection, injury, metabolic stress, abnormal protein deposition, or immune imbalance. Its core lies in the dynamic imbalance among microglia, astrocytes, peripheral immune cells, the blood-brain ...
Research on the cathepsin family is mainly used to elucidate mechanisms involving lysosomal proteolysis, antigen processing, cell death, matrix remodeling, and inflammatory responses. Members such as Cathepsin B, D, K, L, S, and G differ significantly in catalytic type, cellular localization, ...
Intracellular DNA sensing is not always triggered directly by exogenous pathogens. In many noninfectious stress settings, its upstream origin is first a disruption of mitochondrial metabolic homeostasis.
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