Histone methylation is an important epigenetic mechanism that regulates chromatin states and gene expression. Different modification sites and degrees of methylation produce distinct transcriptional effects, and their dysregulation is closely associated with tumorigenesis, impaired cell ...
Epigenetic enzymes do not function solely at the chromatin level. Increasing evidence in recent years indicates that DNA methyltransferases, histone acetyltransferases, deacetylases, and demethylases can influence expression of mitochondria-related genes through classical transcriptional ...