Glycolytic rate-limiting enzymes determine the key nodes from glucose uptake and flux commitment to pyruvate formation. Hexokinase, phosphofructokinase, and pyruvate kinase respectively control early substrate trapping, irreversible mid-pathway flux commitment, and terminal ATP generation in ...
The study of carbohydrate-metabolic enzymes has expanded beyond their classical catalytic roles to include higher-order cellular programs such as replication progression, DNA damage repair, and inflammatory activation. Multiple carbohydrate-metabolic enzymes can acquire moonlighting functions ...