治疗性单克隆抗体中的免疫调控靶点：BAFF与PD-1通路的作用机制
BAFF通路与PD-1通路分别代表治疗性单克隆抗体免疫调控中的两种典型方向。BAFF通路主要调节B细胞存活、成熟和自身抗体产生，适用于自身免疫和体液免疫异常相关研究；PD-1通路主要调节T细胞抑制、耗竭和抗肿瘤免疫反应，适用于肿瘤免疫和慢性抗原刺激状态下的免疫功能恢复。 ...
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BCMA
用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
4 项资源 · 实验方案、常见问题与文章
Immune Regulatory Targets in Therapeutic Monoclonal Antibodies: Mechanisms of the BAFF and PD-1 Pathways
The BAFF pathway and the PD-1 pathway represent two typical directions in immune regulation by therapeutic monoclonal antibodies. The BAFF pathway mainly regulates B-cell survival, maturation, and autoantibody production, making it suitable for studies related to autoimmunity and abnormal ...
Molecular Composition, Receptor-Selective Signaling, and B-Cell Effector Functions of the APRIL Pathway
The APRIL pathway is an important component of the BAFF/APRIL humoral immune regulatory system. Its functional focus is centered on plasma cell survival, maintenance of antibody production, immunoglobulin class switching, and regulation of mucosal humoral immunity. Compared with BAFF, which more ...
APRIL通路的分子组成、受体选择性信号与B细胞效应
APRIL通路是BAFF/APRIL体液免疫调节系统的重要组成部分，其功能重心主要集中于浆细胞生存、抗体维持、免疫球蛋白类别转换以及黏膜体液免疫调节。与更偏向广谱B细胞稳态支持的BAFF相比，APRIL的作用更集中于活化后B细胞、浆母细胞和长寿命浆细胞阶段，其生物学输出高度依赖BCMA、TACI及肝素硫酸蛋白聚糖共同构成的受体与局部呈递环境。 ...
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常与免疫学实验一起研究的技术。
危险品化学品经营许可证（带存储）