Role of the CD2-CD58 Signaling Axis in Immune Synapse Formation, Immune Regulation, and Targeted Therapy
CD2-CD58 interactions stabilize contact between immune cells and target cells and participate in the organization of T-cell and NK-cell immune synapses, amplification of activation signals, and maintenance of effector functions. Loss of CD58 or insufficient CD2 signaling can weaken antitumor ...
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