GSK-3β inhibitor 15 (Compound 54) is a GSK-3β inhibitor ( IC 50 : 3.4 nM). GSK-3β inhibitor 15 inhibits Aβ 1-42 -induced GSK-3β and tau protein phosphorylation. GSK-3β inhibitor 15 inhibits LPS-induced iNOS expression. GSK-3β inhibitor 15 has neuroprotective effects on Aβ 1-42 -induced neurotoxicity. GSK-3β inhibitor 15 can be used for research of Alzheimer’s disease (AD).