Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC 50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei , P. falciparum strains 3D7 and Dd2 with IC 50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei -infected mice with ED 50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice.