GSK3739936 (BMS-986180) is a potent HIV-1 allosteric integrase inhibitor with an IC 50 value of 11.1 nM and an EC 50 value of 1.7 nM. GSK3739936 is also a weak CYP inhibitor (IC 50 >24.3 μM). GSK3739936 shows favorable pharmacokinetic property in preclinical species with rapid absorption, low to moderate clearance and excellent oral bioavailability.