GXF-111, a PROTAC molecule, can promote selective degradation of cellular BRD3 and BRD4-L. GXF-111 has binding affinities for BRD3 BD1 and BRD3 BD2 with K i values of 11.97 nM and 2.35 nM, respectively. GXF-111 can be used for the research of cancer.