Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC 50 of 2.11 nM against hMMP1 , and transcriptional activation activity with an EC 50 of 5.59 nM against MMTV.